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KMID : 0351619700110010119
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Kyungpook Medical Journal
1970 Volume.11 No. 1 p.119 ~ p.127
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Experimental Study on Hemopoietic Effects of Sodium Levothyroxine
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Abstract
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The hemopoietic effect of sodium levothyroxine in the albino rats vas studied with the following results.
1) In rats administered sodium levothyroxine orally at 4 ~cg/kg of body weight daily for four week´s, a significant rise in reticulocyte was noted whereas no noticeable changes mere found in hemoglobin, neutrophil and platelet. Also no appreciable differences were observed in nucleated cell and megakaryocyte counts in marrow, RBC 59Fe uptake and pl~isma 59Fe disappearance half time as compa~,red with those of the control group,
2) In the rats treated with an oral administration of sodium levothyroxine at ~l0~cg/kg of body weight daily for four weeks, significant increases in hemoglobin and reticulccyte were observed whereas both neutrophil acid platelet revealed no significant changes, the nucleated cell count and megakaryocyte counts in the :marrow as well as the plasma ~9Fe disappearancehalf time were not significantly altered but only the RBC ~9Fe uptake was increased as compared with those of the control group.
3) In rats given sodium levothyroxine at 400 ug/kg of body weight daily for fear weeks, both hemoglobin and reticulocyte were increased remarkably compared with those of the 40ugadministered group although neutrophil and platelet were not changed. As compared with those of the control group, both increased nucleated cell count, in the marrow RBC 59Fe uptake, and shortened plasma 59Fe disappearance half time were noted but only the megakaryocyte count disclosed no variation.
4) Rats given sodium levothyroxine orally at 40ceg/kg of body weight daily for four weeks after a total 3.0ml. of blood had beet drawn, exhibited earlier recovery of hemoglobin as well as greater increase in reticulocyte as compared with the control group in which only blood had been drawn.
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